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ROS directly oxidize the glutaminase protein, altering its structure and function, and modulating metabolic pathways, including elevated mitochondrial ROS production, which further affects glutaminase activity
10.1038/ncomms10894 106 NoctorG.QuevalG.MhamdiA.ChaouchS.FoyerC
GH pulse modulation can be observed relatively quickly after exposure in experimental systems, while downstream signaling changes typically appear over longer research durations
Br J Haematol 150 (3): 345-51, 2010
