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6.3 Bioavailability bottleneck of natural products Although natural products have a significant protective effect on the damage of hepatorenal metabolic barrier through multi-component and multi-target regulation, their clinical application is hindered by a significant bioavailability bottleneck

However, this method may induce denaturation in the therapeutic peptides due to exposure to organic solvents and sonication parameters, and is suitable only for molecules with high molecular weight

Curcumin, the active principle of turmeric ( Curcuma longa ), ameliorates diabetic nephropathy in rats