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The first major hurdle that became apparent shortly after the first IGF-1 assay was the discovery of IGFBPs, the presence of which significantly reduced the levels of immunoreactive IGF-1 in samples leading to misleadingly low results

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Key Findings Disparities in outcomes across different patient groups defined based on race, ethnicity, gender, age, socio-economic factors, and other factors are significant and can be attributed to many intersectional drivers related to healthcare awareness, access and delivery, in addition to factors related to genetics While access and delivery of care are major factors driving disparities in outcomes, a comprehensive clinical development program that addresses diversity and ranges from pre-clinical and exploratory studies through randomized confirmatory trials for safety and efficacy through to post-approval real-world studies can advance understanding of optimal patient care, expand access to care, bring earlier insights, and accelerate innovation Stakeholders in the U.S