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The cryo-EM structure of FBXO22-UNC10088 C -NSD2 has missing residues in the interface loop regions that were modeled using the template-based module implemented in SWISS-MODEL 44

They were mainly gastrointestinal, and only one patient in that group discontinued due to side effects
Importantly, in these experimental models, pre-hypoxic treatment with sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (POCA) or oxfenicine, both inhibitors of CPT I, prevents membrane and cytosolic LCAC accumulation in early ischaemia and the genesis of electrophysiological derangements (Yamada et al., 1994)

These are vital synaptic proteins in neurons that respond to the AO continual presence (79)
