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Although serine can be derived from the degradation of cellular proteins and the interconversion with glycine, these pathways alone are insufficient to meet the metabolic demands of biological tissues, especially in pathological conditions ( de novo serine synthesis pathway (SSP) substantially enhances the intracellular availability of serine ( The de novo serine synthesis pathway, also referred to as the serine biosynthetic pathway, is a branch pathway of glycolysis

The mechanisms involved likely rely on the gene regulatory effects of vitamin C [79,89,199,200]

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The Se levels of the subjects in this study were inferred from the diet, so it has an information bias