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Therefore, the first place you need to look when the benefits of a methyl-B12 shot seems to wear off too soon is to retry the shots at the same dose and frequency but make the angle of attack much more severe, much closer to the horizontal plane, just under the skin

As opposite, in the extracellular medium, a detectable decrease in the concentrations of these proteins would be less likely due to the absence of the cellular machinery for protein degradation