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The results suggested that treatment sustained for more than 1 year should be continuous still if the metabolic parameters were without correction as observed in RU and PM

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2.50 days, P =0.002), compared with those who received lactulose alone [259]

It seems to be a consensus that OS has been implicated in the pathogenesis of multiple disease states and may be a common pathogenic mechanism of many major psychiatric disorders [101], including AD [99,102,103,104,105], depression [101,103,106,107,108], ALS [109,110,111,112,113], peripheral nervous system diseases [114,115,116], etc

Also, a small non-randomized study 15 in two older adults treated with ALC (2 g/day for 12 weeks), reported a decrease in HDRS scores from 15 to 0 and from 20 to 3 by week 12 and compared outcomes with six non-depressed controls