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Notably, all patients had previously been treated with pentosan polysulfate, which is currently the only FDA approved treatment for interstitial cystitis, and had not responded

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Not sure if thats why it was so painful

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on The Joe Rogan Experience

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Research in rodents indicates that not only does epithalon activate this gene, it activates fibroblasts, the cells that produce and maintain MMP2 as well as other components of the extracellular matrix like collagen and elastin

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doi: 10.3390/ijms24076269

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