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The pharmacology of mTOR inhibition

The incidence of renal dysfunction is related to the severity of the acetaminophen ingestion * : Patients with liver involvement but no hepatic failure: ~5% Patients with severe poisoning:10% Patients with acute hepatic failure: ~50% Pathogenesis * Direct toxicity by toxic metabolites of APAP, oxidized by CYP in the kidney

In the immune cells of senior or immune-compromised individuals, ROS is increased due to decreased glutathione, which causes dysregulation of immune responses, particularly of T cell-mediated functions

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