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Parkinsons disease (PD) PD is a neurodegenerative disease, and its pathogenesis is closely related to the abnormal aggregation of -synuclein (-syn), loss of dopaminergic neurons, and ROS-induced oxidative stress [166, 167]

By contrast, the Fischer rat, an inbred strain that is five times more susceptible to AFB 1 - induced liver cancer than the Wistar rat [34], possesses 20-fold less hepatic AFB 1 -GSH-conjugating activity than the mouse

Generation of ROS invigorates oxidation of proteins that might act as signalling targets, comprising kinases, transcription factors (TFs), as well as proteins linked with stress amelioration

(PubMed) 113
