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Crucially, this therapeutic benefit was achieved with a favorable safety profile, as QLQX demonstrated tolerability comparable to placebo, with no significant hepatic or renal toxicity and no increase in arrhythmias or other major adverse events

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However, this approach does not account for situations in which the neutralization assay had neutralization titers below the LOD, therefore we also used a second method, in which we estimated this value by extracting the neutralization titers from the figures in each immunogenicity study (Supplementary Table 1) and computing the mean neutralization titer for vaccinated and convalescent individuals in each study using censoring regression (equation 1)