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Transporter dysfunction within the endolysosomal system leads to diverse systemic phenotypes

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Escaping death: mitochondrial redox homeostasis in cancer cells

O 2 is the conjugate base of a weak acid HOO (de Grey 2002) Since superoxide does not react with DNA directly, in the context of DNA damage is of important dismutation reaction of superoxide radical Although the concentration of hydroperoxyl radical (HOO ) is low, this reaction is significantly faster than the uncatalyzed reaction involving two molecules of superoxide radical The superoxide anion radicals can be formed in biological systems as a consequence of thiol-mediated repair of radicals (R ) by thiols (RSH), resulting in the formation of thiyl radicals (RS ) (Valko et al

However, research is ongoing