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(PubMed) Marti-Carvajal AJ, Sola I, Lathyris D, Dayer M

Preclinical research demonstrated that NNMT inhibition with 5-Amino-1MQ reduced white adipose tissue mass by ~35% , shrank adipocyte size by 30-40%, and lowered plasma cholesterol by ~30% all without affecting food intake

it is whether they get a meaningful amount of the vitamin at all