glutathione and cataracats Oxidative stress inflammation as possible causes of age-related glutathione depletion and cataracts Deficiency

doi: 10.1016/S0002-9440(10)62478-9

Blocking FOXO4, which inhibits the activation of P53, causes senescent cells to undergo apoptosis by P53 activation, without affecting healthy cells around them, and has anti-aging effects which may have potential applications in the treatment of numerous age-related diseases, as well as an adjunct to treatment for certain forms of cancer

These users report appreciating treatment benefits while active but watching improvements gradually fade over months post-discontinuation, with timeline showing first 2 months maintaining most benefits creating initial optimism, months 2-4 showing noticeable decline returning toward baseline, months 4-8 continuing regression approaching pre-treatment status, and stabilization occurring 60-80% back toward original baseline with only modest long-term improvement retention

However, this strategy is only attractive if the therapeutic agent itself is not a substrate for CPA, or if the case, that its functional activity is not negatively affected by C-terminal cleavage

Lipid peroxidation and immune biomarkers are associated with major depression and its phenotypes, including treatment-resistant depression and melancholia