glutathione rest leg syndrome A unifying iron–dopamine–irisin/BDNF hypothesis for the Restless Legs Do You Have Restless Legs

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[PubMed: 25680499] (Extensive review of liver injury due to HDS mentions that kava has been implicated in more than 100 cases of clinically apparent liver injury including 9 instances of acute liver failure, 3 of which resulted in deaths)

Injection site reactions, including redness, swelling, or itching, are usually unrelated to dose level and instead reflect injection technique issues or localized sensitivity