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Cai Q, Zakaria HM, Simone A, Sheng Z-H

also observed metabolic disturbances in the serum of MA abusers, particularly perturbations in energy and amino acid metabolism 8

More importantly, due to better hydrophobicity than DON and JHU083, JHU395 allows for better penetration into the brain and effectively kills MYC-expressing medulloblastoma cells with decreased peripheral exposure
Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

For each benefit, you will find the mechanism of action and reference studies