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In SURMOUNT-1 (NEJM 2022, 2,539 adults with obesity), the 15 mg arm averaged 22.5% body weight loss at 72 weeks, the 10 mg arm 21.4%, and the 5 mg arm 16.0%

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However, peptides have intrinsic weak points, and they did not provide encouraging results in vivo , likely due to their physical, chemical and structural instability and low membrane permeability (112, 119, 121)

Sublingual B12 bypasses intestinal absorption issues and potential barriers caused by genetic variants, which makes it a more accessible treatment option for vitamin B12 deficiency

T2D is a multifactorial, complex disease and can be controlled by diet modifications, control of physical activity, weight reduction, etc