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Second, in the 1980s, vascular endothelial cells were shown to produce nitric oxide from l-arginine, which explained the biological effects attributed to endothelium-derived relaxing factor (Furchgott and Zawadzki 1980

doi: 10.1523/JNEUROSCI.5808-11.2012

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Final data have not yet been published, but preliminary observations suggest that reducing the CSI dose to 15 Gy will result in fewer endocrinopathies, low incidence of hearing loss, and improvement in neurocognitive outcomes