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doi: 10.3389/fendo.2024.1414463 Received 08 April 2024 Accepted 30 April 2024 Published 14 May 2024 Volume 15 - 2024 Edited by Marta Letizia Hribal, Magna Grcia University, Italy Reviewed by Daniel P

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Although the structure of the melanocortin1 receptor (MC1R) and its variants in melanoma risk have been previously described, the impact of constitutive and pharmacologic activation of MC1R have not been extensively covered