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Frataxin silencing promotes longevity through multiple mechanisms, including mitophagy activation, HIF-1 signaling, and ferroptosis inhibition (Schiavi et al, 2023, 2015, 2013)
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We discovered that the daf-16d/f , but not daf-16a or daf-16b isoform, sufficiently restores the fat storage increase in the daf-11;daf-16 double mutants (Fig

The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19
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