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14 Coffee and B12 absorption Research into coffee consumption and its effect on B12 absorption is limited

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Marks3 hypothesized that a change in the location and distribution of melanin might be involved, observing that megaloblastic anemia is associated with a defect in the transport of melanin and its incorporation into keratinocytes

In drawing on studies that extend from clinical epidemiology, through genetics, pharmacotherapy and animal models, to cell biology and biochemistry, we have aimed to provide a comprehensible and accessible narrative, although this comes at the expense of a fully comprehensive and systematic (and inevitably longer) analysis