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Concurrent overexpression of c-Met and Akt leads to synergistic activity of these proto-oncogenes, resulting in rapid cancer expansion [89]
The physiology of vitamin B-12 is a multistep process that is characterized by multiple trafficking events, associations and dissociations among several binding/carrier proteins, specific and multiligand receptor-mediated endocytosis, intracellular trafficking into different cellular compartments, and protein-specific controlled exit (1, 2)
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