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Thus, the evidence suggests a common mechanism in tumor progression and autoimmune disease development involving the regulation of HIF-1, which contributes to the differentiation of T cells into pro-inflammatory cells characteristic of many autoimmune diseases ( Figure 5 )
Carboxymethyl lysine (CML), reported as the most abundant AGEs in vivo , is formed by oxidative degradation of Amadori product fructoselysine
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[Google Scholar] 30.Liu SH, Pan IH, Chu IM
