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2024, ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

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Preclinical research evidence Animal Experiments Obese mouse model: After subcutaneous injection of AOD 9604 (250 g/kg) daily for 8 weeks, the body weight of obese mice decreased by 12%, the subcutaneous fat mass decreased by 25%, and the weight of epididymal adipose tissue decreased significantly

For individuals with BMI above 30 or BMI above 27 with comorbidities, FDA-approved GLP-1 receptor agonists (semaglutide, tirzepatide) have far stronger evidence and produce dramatically greater weight loss