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BMC Cancer 13:601 Zhdanov AV, Waters AH, Golubeva AV, Dmitriev RI, Papkovsky DB (2014) Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling

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Here we show that lobeline delays SG dissolution post-hypoxia in a dose-dependent manner, leading to a higher percentage of cells containing SGs, an increased number of SGs per cell, sustained ISR activation and reduced protein synthesis