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Conversely, Hantson and coworkers [83] recently reported the case of a 47-year-old epileptic man in whom parenteral VPA therapy was associated with a severe hyperammonaemic encephalopathy (peak ammonia concentration 411 mol/l) without any biological signs of hepatotoxicity

The main biological mediators (and their properties) present in Peyronies disease are listed in Table 1: nuclear factor-B, i-NOS, TGF-1, PDGF, IL-1, bFGF, PAI-1, TNF-alpha, tissue inhibitors of metalloproteinases (TIMPs) [5,20,25,39,42,43,45,48,49,50,52,56,57,58,59,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88] (see Figure 1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Conrady C.D., Joos Z.P., Patel B.C