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GSDMD activation relies on inflammasome formation, triggering inflammatory caspases ( 1, 4, 5, 11)

Although the VPA model effectively recapitulates key ASD phenotypes, future work must validate these findings in genetic subtypes (e.g., Shank3 KO) and decipher causal microbiota-neuroimmune crosstalk via fecal transplantation

Statistical significance was determined at a P -value 0.05)

Results ATG2A undergoes depalmitoylation at its C-terminal during cell starvation Research conducted on yeast has demonstrated that Atg2 serves as a phosphorylation substrate for Atg1, although it is unlikely that Atg1-dependent phosphorylation is directly related to the role of Atg2 in autophagy (Papinski et al, 2014)

Recent studies suggest that noninvasive plantar stimulation may enhance peripheral sensory processing and reduce FOG episodes