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( B ) The tryptophan-to-phenylalanine substitution at position 65 of the gp34 1-179 sequence designated as gp34 1-179W65F variant was used as a non-Fc binding control

Reactive oxygen species (ROS) are generated through interaction of the excited state chromophore with a variety of substrates, which go on to oxidatively damage biomolecules (37)

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10 In 1976, Rinderknecht and Humbel 11 isolated two active substances from human serum, which owing to their structural resemblance to proinsulin were renamed insulin-like growth factor 1 and 2 (IGF-1 and 2)

Some reports ( Reference Betz, Ren and Ennis 53 Reference Seekamp, Hultquist and Till 56 ) have indicated that riboflavin can alleviate oxidative injuries in these situations, probably through its ability to scavenge free radicals
