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178,179 Additionally, cAMP can activate Rap1 through EPAC (Exchange Protein directly Activated by cAMP), 180,181,182 which is involved in regulating insulin secretion

Nonetheless, recent evidence suggest that there is a fine line between protective and pathogenic astrocyte-mediated functions of BDNF, as astrocytes themselves respond to increased levels of BDNF with the secretion of neurotoxic amounts of nitric oxide (NO), demonstrating a sophisticated feedback loop that prevents excessive BDNF signaling (129)

Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain