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In chronic prostatitis, ROS induce lipid peroxidation of cell membranes, disrupt the barrier function of cells, and damage mitochondria, leading to energy metabolism disorders

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Side effects are typically mild injection-site reactions, flushing, increased heart rate, nausea, headache

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Sputum sampling may be spontaneous or induced

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Patients were randomized to apply glutathione as 2% GSSG lotion and a placebo lotion in a split-face protocol twice daily for ten weeks

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Proposed mechanisms include: DSIP-induced upregulation of downstream receptor systems that outlast the peptide itself

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