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The most common mutation is V600E, which results in constitutive activation of the MAPK pathway
It is now understood that these pathways can also involve cross-talk, and that autophagy can act as an additional method for eliminating ubiquitinated proteins under conditions of extreme stress
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Acta Haematol 145(5):529-536, 2022
However, due to their reversibility, these side effects do not pose any lasting danger
