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Biol Trace Element Res

65 Macrophages can be categorized into M1 (classically activated) macrophages that contribute to tissue destruction and secrete pro-inflammatory factors and M2 (alternatively activated) macrophages that produce anti-inflammatory factors

Concurrently, they stimulate the production of transforming growth factor-beta 1 (TGF-1) and the C-terminal propeptide of type I collagen (CICP)biomarkers indicative of active collagen synthesisthereby facilitating extracellular matrix deposition, maturation, and dynamic tissue remodeling during wound healing

DOI: 10.2337/db16-0649 38

Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 9) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors (258, 259)