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Major Surgery Guideline Statement 22 Major surgery (substitution cystoplasty, urinary diversion with or without cystectomy) may be undertaken in carefully selected patients with bladder-centric symptoms, or in the rare instance when there is an end-stage small fibrotic bladder, for whom all other therapies have failed to provide adequate symptom control and quality of life improvement
Statistical analysis All experiments were performed at least in triplicate, and results are presented as means standard deviation (SD)

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