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The consequences extend beyond simple fatigue: B12 deficiency can trigger mood disturbances, cognitive decline, nerve damage, and compromised immune function

Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide

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Two studies showed that NAMPT protein expression is enhanced in skeletal muscle following exercise 326,327

B vitamins work synergistically to support testosterone production - B6 suppresses prolactin, B12 enhances energy metabolism, and folate supports methylation pathways essential for hormone synthesis