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Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage

Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder
10.3390/antiox10020154 131 RochetteL.DogonG.RigalE.ZellerM.CottinY.VergelyC

The analysis of the catalytic parameters demonstrated a reaction rate of 0.0257 h 1 , turnover number of 38.2, and turnover frequency of Ru(II)-OH of 0.3141 h 1 (Supplementary Table 1)
