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Another pathognomonic feature of LAL-D is birefringent cholesterol ester crystals in hepatocytes and Kupffer cells, using polarized light on electron microscopy
Some patients are unaware of the presence of the pigmented macules while others report noting their appearance for weeks to years [26, 29, 32]

We identify multimodal based PD subtypes by unsupervised machine learning using clinical, motor, cognitive, brain structure, and connectivity data

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[DOI] [PubMed] [Google Scholar] (34).Arthur M