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22 Data Analysis Quantitative synthesis was conducted using randomized controlled trials with extractable outcome data

To verify whether the statistical power of our MR analysis meets the requirements, we used the mRnd method to calculate it and found that the statistical power reached 0.94, thereby demonstrating the reliability of our study

Am J Physiol Endocrinol Metab 295 , E10091017, doi: 10.1152/ajpendo.90558.2008 (2008)

This is of primary importance, as most Rett mutations occur de novo, and the disease is usually diagnosed when the symptoms are present, which also means that any therapeutic intervention will be administered to Rett patients after disease onset