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[DOI] [PMC free article] [PubMed] [Google Scholar] 188.Xu T, Dong Z, Wang X, Qi S, Li X, Cheng R, Liu X, Zhang Y, Gao MQ

Some ferroptosis-targeting agents have poor pharmacokinetic properties, such as low solubility, high metabolic clearance, low cellular permeability, and short half-lives ( Figure 7 )

Others focused on vascular recovery and broader protective effects throughout the body

Using TRRUST (24) we queried differentially up and down regulated genes in response to BDG exposure against a database of TF cistromes based on ChIP-chip and ChIP-seq datasets ( Figure 3C and Supplementary Table 5A )

This triggers neuronal membrane depolarization, increased potassium efflux, and sodium influx, disrupting Ca 2 -ATPase function and leading to high intracellular calcium levels [12, 55]