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This contributes to the plasticity of BMAT, including BMAT expansion in common physiological or pathological conditions, and BMAT catabolism under certain extreme circumstances, which are often associated with malnutrition and/or systemic inflammation

Mechanistically, these flavonoids increased dichlorofluorescein (DCF) oxidation, suggesting their ability to elevate intracellular ROS levels and activate p38 Mitogen-activated protein kinases (MAPKs)

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Journal of cardiovascular translational research