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Second, they found that Sirt1 protein expression is significantly correlated with NNMT expression in hepatocytes [14]
NNMT is expressed abundantly in adipose tissue, where it has been associated with fat cell size and lipid storage dynamics

References Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes

There is no validated lab marker for NNMT inhibition outside research labs

The enhanced metabolic efficiency also supports better energy balance, making it easier to maintain weight loss results long-term
