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Metabolic effects of ketogenic diets: exploring Whole-Body metabolism in connection with adipose tissue and other metabolic organs

In another asthma model related to oxidative stress, namely toluene-diisocyanate-induced (TDI), mice and rats exposed to oxidized graphene, single-walled carbon nanotubes, nano aluminum oxide, or other highly pro-oxidative substances, vitamin E administration decreased ROS [382,383,394,395]

Protonation of the oxidant accelerates the reaction because the protonated form is a better electrophile, which is an opposite effect to the aforementioned favorable deprotonation of the thiol

The five most upregulated genes were aldol-keto reductases (maximum 30.2 fold), alcohol dehydrogenases (maximum 11.65 fold) and nitrate reductase (8.06)

Glutathione inhibits tyrosinase the key enzyme in melanin production and shifts melanin synthesis towards lighter phaeomelanin