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This study is reported in accordance with the ARRIVE guidelines for reporting animal research

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378 Astrocytic overload with iron however significantly reduces glutamate clearance by down-regulation expression of EAAT1 glutamate transporters 379 and impairs operation of the glymphatic system

This interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (CGRP), pituitary adenylate cyclase activating polypeptide (PACAP) and/or cortical spreading depression (CSD) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (NLRP3) inflammasome formation, activated microglia, and reactive astrocytes

Research gaps and controversies in chronic traumatic encephalopathy: A review