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[Organic and Biomolecular Chemistry, 2009, vol

These agents, while triggering ROS production, also impair endogenous antioxidant defenses, thereby enhancing lipid oxidation

[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Nauman G., Gray J.C., Parkinson R., Levine M., Paller C.J

4.7 Sulfur-containing amino acids Metabolic pathways related to sulfur-containing amino acids, represented mainly by methionine (Met), cysteine (Cys), and their derivatives such as taurine (Tau), can respectively connect methyl donor cycling and redox homeostasis regulation: Met affects methylation capacity through SAM generation, Cys participates in redox balance and signaling regulation through GSH/H 2 S, and Tau is associated with antioxidation and mitochondrial homeostasis ( Sulfur-containing amino acid-related metabolic pathways, mainly including methionine, cysteine, and taurine, are characterized in macrophage polarization by the intersecting properties of methyl donor cycling-transsulfuration-redox homeostasis. Methionine (Met) not only serves as a substrate for protein synthesis within cells, but also generates SAM through the methionine cycle