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When a compound has no completed human trial, there is by definition no safety data in any subgroup no pregnancy data, no hepatic-impairment data, no interaction data with common metabolic or endocrine medications

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NNMT inhibition plus a lean diet accelerates weight/fat loss, improves body-composition indices, and normalizes several liver pathologies versus diet alone [3,4]

Akinmoladun I, Afolabi O, Jolaoso A, et al

A deficiency in Vitamin B12 can lead to fatigue and decreased energy, as your body struggles to deliver adequate oxygen to your cells