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Mitochondrial cholesterol accumulation also impairs antioxidant glutathione (GSH) import into mitochondria, leading to increased mitochondrial oxidative stress and enhanced A neurotoxicity in the APP/PS1 transgenic mouse model of AD (Fernandez et al., 2009)

Med Phys 27:701-711, 2000

Immunochemical identification of the alpha 1- and alpha 3-subunits of the GABAA-receptor in rat brain

22 However, SAMe was ineffective in treating already existing HCC as the normal liver was able to up-regulate compensatory mechanisms (such as GNMT expression) to dispose excess SAMe and prevent its accumulation

M., Al-Malki, A.L., Wassef, M