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This medicine comes from the extract of the USA that has been used since the olden days for skin whitening

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Estrogen receptors alpha (ER) and beta (ER) belong to the so-called classical family of estrogen receptors, while the G protein-coupled estrogen receptor 1 (GPER-1) represents a non-classical estrogen receptor mainly located in the plasma membrane

Interventions Enrolled patients were randomized into two treatment groups: Control Group (C) (30 patients): treated according to standard practice with MMI and beta-blockers only