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Description
The soluble protofibrils formed from -synuclein exert their cytotoxicity through disruption of mitochondrial function, promotion of autophagy, lysosomal impairment and loss in regulation of calcium homeostasis (Van Laar et al., 2020), the two primary reasons accounting for loss in cellular homeostasis
[PubMed 4203556] 203
10.1016/j.cell.2015.05.056 108 WuC.-Y.YangY.-H.LinY.-S.ChangG.-H.TsaiM.-S.HsuC.-M.et al (2021)
10.1038/s41589-018-0031-6 49 GaschlerM
PMID: 22781841
