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The majority of what is known comes from controlled laboratory environments where variables such as species, dosage, timing, delivery route, and injury model differ significantly from one study to another

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Tendler CL, Greenberg SJ, Burton JD, Danielpour D, Kim SJ, Blattner WA, Manns A, Waldmann TA

[PubMed: 2998878] 6

Many compounds are biologically active and should be handled in controlled environments using appropriate PPE (Personal Protective Equipment)
