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Impaired autophagy, oxidative stress, and reactive oxygen species Accumulation of Gb3 in lysosomes interferes with the autophagic process (76), leading to the accumulation of damaged organelles including mitochondria (77) and protein aggregates, triggering inflammation

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Phytomedicine 2014, 4 (1), 114

The gut microbiota and CVDs The human gut is colonized by approximately 100 trillion microorganismsincluding beneficial bacteria, neutral bacteria, and pathogenic bacteriawhich cooperate to maintain homeostasis of the gut microecology ( Bacteroidetes and Firmicutes account for approximately 90% of the total gut microbial abundance, followed by Proteobacteria (5-10%), Actinobacteria (3%), and Verrucomicrobia ( Intestinal dysbiosis refers to imbalance in the composition and abundance of gut microbiota and is associated with numerous diseases and phenotypes ( Supplementary Table 1 )

(1997) published findings in the Journal of Biological Chemistry demonstrating that IGF-1-mediated signaling through PI3K is essential for myoblast differentiation