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Its evolution may have occurred in association with the Great Oxidation Event (2.5-2.0 bya) when the Earths atmospheric concentrations of oxygen rose profoundly because of its release from the photosynthesizing microbes, cyanobacteria ( Figure 2 ) (62, 63)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Amatore D., Celestino I., Brundu S., Galluzzi L., Coluccio P., Checconi P., Magnani M., Palamara A.T., Fraternale A., Nencioni L

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A randomized phase II study of low-dose decitabine versus low-dose azacitidine in lower risk MDS and MDS/MPN